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The spectacular role of the human microbiome and spore probiotics in preventing metabolic endotoxemia

  • 28 Jun 2018
  • 18:30 - 20:30
  • London, 25 Percy Circus, WC1X 9EU


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The spectacular role of the human microbiome and spore probiotics in preventing metabolic endotoxemia, the number one cause of mortality worldwide.

Presented by: Kiran Krishnan, Research Microbiologist & Chief Science Officer, Microbiome Labs, LLC.


You are more bacteria than you are human with 10 trillion human cells outnumbered by over 100 trillion bacteria cells in and on your body.  The human genome contributes just 1% genetic material to daily metabolic function compared to the 99% that is contributed by the microbiome. An often-overlooked role of the microbiome is to prevent metabolic endotoxemia and the inflammatory devastation that follows. Approximately 50% of the western population suffers from metabolic endotoxemia, which can remain sub-clinical for decades. The condition is characterized by increased serum endotoxin concentration during the first five hours of the post-prandial period. This increase in serum endotoxin concentration then triggers systemic inflammation resulting in elevated interleukin-6, interleukin-1-alpha, interferon-gamma, triglycerides and post-prandial insulin levels. Many of these critical markers have been shown to be at the root cause of a variety of chronic diseases.

Current studies demonstrate a strong correlation between metabolic endotoxemia (ME) and the risk or onset of conditions such as cardiovascular disease, diabetes, obesity, hypogonadism, autoimmunity, and even mood disorders such as anxiety and depression. Metabolic endotoxemia is caused by a failure of the microbiome to protect its host while processing food. Kiran will discuss the danger of having metabolic endotoxemia and why this condition is being called the number one cause of mortality worldwide. He will explain the role of the microbiome in protecting its host against ME, and will share clinical strategies to prevent ME and reverse existing conditions associated with ME.


Kiran Krishnan is a Research Microbiologist and has been involved in the dietary supplement and nutrition market for the past 18 years. He comes from a strict research background having spent several years with hands-on R&D in the fields of molecular medicine and microbiology at the University of Iowa. Kiran established a Clinical Research Organization where he designed and conducted dozens of human clinical trials in human nutrition. Kiran is a co-founder and partner in Nu Science Trading, LLC.; a nutritional technology development and research company. Kiran is also a co-founder and Chief Scientific Officer at Microbiome Labs. In his career, he has developed over 50 private label nutritional products for small to large brands in the global market. He is a frequent lecturer at international Medical and Nutrition Conferences and is known as a subject matter expert on the ‘Human Microbiome’. He is currently involved in 10 novel clinical trials on probiotics and the human Microbiome and is on the Scientific Advisory Board for 7 other companies in the industry.  Kiran brings his extensive knowledge and practical application of the latest science to his educational lectures, which are both informative and entertaining!

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