By Peter H. Kay
1. Summary of cancer causation.
This includes introduction to many of the body’s defence and repair mechanisms that are relevant to cancer causation and treatment.
2. Factors affecting chemotherapy.
Different kinds of drugs. Factors affecting their efficacy, genetics and importance of cytochrome P450 enzymes, CYP2D6 and CYP3A4, blood factors, genetic considerations, pharmacogenetics. The significance of multi-drug resistance. Cancer stem cells.
3. What can be done to help chemotherapy and radiotherapy work as effectively as possible.
4. Radiotherapy, pros and cons.
How radiotherapy works. Genetic considerations, radiogenomics. Difficulties with radiotherapy. DNA repair systems. Low dose radiation, benefits.
5. Introduction to immunological aspects.
Immunological factors. Drug/immune reactions. Monoclonal antibodies. Stem cell transplantation, graft versus host considerations. Dendritic cell therapy. Checkpoint immunotherapy. CAR T cell therapy.
6. Introduction to photodynamic therapy.
7. Understanding spontaneous remission.
Oncolytic viral therapy. Infectious agents, Coley’s toxins.
8. Cancer cell specific metabolic pathways. Significance of PARP inhibitors in breast and ovary cancer.
How they can be used to develop alternative approaches to cancer treatments.
9. Directions to determine the genetic types of important enzymes.
Is chemotherapy going to be helpful or harmful? Who to contact for genetic typing of genes that encode CYP2D6, CYP3A4, DPD and p53 for example.
10. Supplementation and dietary considerations.
About Peter H. Kay
Dr. Peter H Kay PhD is a world renowned scientist, molecular pathologist, immunologist and geneticist.
Dr Peter Kay was born in the UK in 1945. In the early part of his scientific career, he specialized in blood group serology and haematology. In 1974, he moved to Australia and became involved in tissue transplantation serology and autoimmunity. He later became a member of the Dept of Pathology at the University of Western Australia, specialising in Immunopathology. In the late 1980s he was awarded his PhD, subject matter, Immunogenetics.
In 1989, he founded the first Molecular Pathology laboratory in Western Australia in the Faculty of Dentistry and Medicine at the University of Western Australia, and remained as Head until he retired from Academia in 2001. During that time, he conducted world class research and launched the careers of many post-graduate students. He has published over 80 peer reviewed articles in prestigious international scientific journals.